Nicotinamide mononucleotide (NMN) supplements are currently considered the best NAD+ enhancers on the market. If you have come across this article, you are probably aware of the benefits of NMN in relation to anti-aging research. This has led to a surge in interest in NMN supplements, and with a plethora of brands available, determining the most reliable investment can be challenging. Below we present the best NMN products.
Three manufacturers, GenF20 Liposomal NMN+, Wonderfeel, and OMRE, offer premium NMN capsules that aim to promote healthy aging. Each product has unique features and benefits, making them stand out from the rest.
Best Product: GenF20 Liposomal NMN+
GenF20 Liposomal NMN+ is a renowned manufacturer that produces GMO-free, gluten-free, soy-free, additive-free, preservative-free and dairy-free capsules under strict GMP and US standards.
These capsules undergo third-party laboratory testing at every stage of production and are FDA-regulated for safety and efficacy. A key benefit of Liposomal NMN+ capsules is their antioxidant content, which promotes healthy NAD+ levels and slows ageing.
Customers can earn redeemable points based on referrals or subscription length, and GenF20 Liposomal NMN+ products are priced between $58.95 and $69.95, making them a competitive option.
- Manufacturer: GenF20 Liposomal NMN
- Pros: Highly Effective, Best Ingredients, Tested by Independent Laboratories, Money-Back Guarantee
- Cons: –
- Rating: ⭐⭐⭐⭐⭐
2nd Place: WonderFeel Youngr
Wonderfeel offers Youngr NMN, a supplement designed to support healthy ageing with antioxidants, sirtuin activators and 900mg of NMN. Users report benefits such as improved energy, memory, skin elasticity and sleep.
The supplement is recommended to be taken in the morning with high-fat, healthy foods to increase the bioavailability of resveratrol and slow ageing. Wonderfeel provides access to customer reviews for more information on the product and is currently offering an introductory price for both subscriptions and one-off purchases, allowing customers to save $15 and lock in the price.
It is important to remember that while NMN supplements offer benefits, they are not a substitute for medical treatment and regular check-ups with a healthcare provider are still recommended for optimal health.
- Manufacturer: Wonderfeel
- Pros: This product boasts a unique patented formula developed by a Harvard MD, offering a powerful 900mg dose of NMN per serving. Satisfied customers have given glowing reviews, highlighting its various advantages such as increased energy, better memory, and enhanced skin elasticity.
- Cons: The available size options for this product are somewhat limited.
- Rating: ⭐⭐⭐⭐
3rd Place: OMRE NMN
OMRE is a premium supplement containing 500mg of 98% pure NMN combined with 500mg of 98% resveratrol, the two most well-known molecules in ageing research. OMRE combines them in a single product, making it more cost effective and reducing the number of pills to take. This supplement is made in the USA, contains no additives and is subject to third party testing for added reassurance.
In conclusion, these three manufacturers offer premium NMN capsules that promote healthy ageing with their unique features and benefits. It is recommended that customers carefully evaluate each product and consult with a healthcare professional before adding them to their routine.
- Manufacturer: OMRE
- Pros: No filler or artificial additives, Vegan, 3rd Party tested, Made in USA, Composed of 98% pure NMN and resveratrol, 30-day Money-Back Guarantee
- Cons: Lack of cost-effectiveness
- Rating: ⭐⭐⭐⭐
4th Place: Renue By Science
Renue Lipo NMN is a promising liposomal form of NMN, a molecule known for its potential anti-aging properties. The encapsulation of NMN in a lipid sphere is thought to enhance its absorption, but conclusive evidence is currently lacking.
While there are no studies to prove that liposomal NMN is absorbed more efficiently than standard NMN powder, some supplements have shown improved absorption when delivered in liposomal form. Renue by Science, a reputable supplement manufacturer, has utilised this technology to create a high quality NMN supplement that may offer enhanced benefits to users.
In addition to its innovative liposomal delivery, Renue’s NMN supplement is formulated using rice flour, a natural and hypoallergenic ingredient that is free of artificial additives. This attention to detail reflects Renue’s commitment to producing a pure and effective product.
- Manufacturer: Renue by Science
- Pros: Liposomal NMN, 500mg NMN in each serving, 3rd party testes, No Additives, No Filler
- Cons: Quite Expensive
- Rating: ⭐⭐⭐
5th Place: Youth & Earth
Youth & Earth is a reputable British brand that specializes in NMN supplements. This brand has built a solid reputation for itself by adhering to strict quality standards and prioritizing customer satisfaction.
One of the distinguishing factors of Youth & Earth is its commitment to third-party testing. All their NAD boosters undergo rigorous third-party testing to ensure their purity and efficacy. The company provides certificates of analysis on their online store, which further establishes their transparency and reliability.
In addition to their quality assurance measures, Youth & Earth offers attractive multi-order discounts that make their products a great value for money. Customers can purchase larger quantities of their NMN supplements at discounted rates, making it easier to maintain a consistent supplement regimen.
Overall, Youth & Earth is a well-respected British NMN brand that prioritizes quality, transparency, and affordability. With their rigorous testing protocols, customers can trust that they are getting a pure and effective product. Their multi-order discounts also make it easier to maintain a consistent supplement routine at an affordable price point.
- Manufacturer: Youth & Earth
- Pros: Multi Pack Discounts, Offer other NAD boosters than NMN, British Brand
- Cons: Lack of cost-effectiveness
- Rating: ⭐⭐⭐⭐⭐
6th: Double wood NMN
Double Wood is a well-known and trusted brand in the supplement industry, with a reputation for producing high quality products. Their NMN supplement is no exception, offering a dose of 250mg per serving in the form of two capsules. This dose is lower than some other NMN supplements on the market, making it a good option for those looking to start with a lower dose.
One notable aspect of Double Wood’s NMN supplement is its clean formula. The product does not contain magnesium stearate or silicon dioxide, which are common fillers in many supplements. Instead, the capsules are filled with rice flour, a natural and hypoallergenic alternative.
However, it should be noted that the capsules themselves are made from gelatin, which may not be suitable for vegetarians or vegans. Double Wood are also transparent in their labelling, clearly stating that the capsules contain gelatine.
- Manufacturer: Double Wood NMN
- Pros: No silicon dioxide or magnesium stearate, Made in USA
- Cons: Itchiness, sweating, dizziness and nausea have been reported in some cases
- Rating: ⭐⭐⭐
What is NMN?
NMN, or nicotinamide mononucleotide, is a precursor to NAD (nicotinamide adenine dinucleotide). Essentially, when two NMN molecules combine, they form NAD. However, NMN is only one of several intermediate molecules in the NAD formation process. The process starts with vitamin B3, also known as niacin or nicotinamide.
Our cells combine vitamin B3 with sugar to form a compound called nicotinamide riboside (NR). Phosphate is then added to NR to form the compound NMN. In other words, NMN = vitamin B3 + sugar + phosphate. Finally, two NMNs combine to form NAD.
Our cells naturally produce NMN as part of the NAD synthesis process. In summary, NMN is an intermediate molecule in the pathway leading to NAD production. Cells naturally synthesise NMN from vitamin B3. Taking NMN supplements increases NAD levels because NMN acts as a direct precursor, bypassing the first two steps in the NAD production pathway.
And the best NMN supplements will
- Have >98% purity NMN
- Contain no fillers or additives
- Be produced by a reputable manufacturer in an FDA and GMP certified facility
- Have undergone 3rd party testing to verify purity
- With these factors in mind, the following are the leading NMN brands currently available.
The benefits of NMN supplements
NMN supplements are primarily promoted as an anti-aging solution to improve various aspects of health, such as energy production, metabolism and cognitive function. NMN, which stands for nicotinamide mononucleotide, serves as a precursor to the coenzyme NAD+, which is essential for many cellular processes, including energy production, DNA repair and gene expression. Essentially, NAD+ is essential for maintaining normal cellular function.
NAD+ levels decrease with age. By the time a person reaches their 30s, NAD+ levels have dropped to half of what they were in adolescence.
Some studies suggest that NMN supplementation can increase NAD+ levels in the body, which may provide a number of health benefits, such as
Anti-aging effects:NMN may help repair damaged DNA and increase cellular energy production, potentially slowing the ageing process and reducing the risk of age-related diseases.
Improved metabolism: NMN may improve insulin sensitivity, glucose tolerance and stimulate fat metabolism, potentially aiding in weight management and reducing the risk of type 2 diabetes.
Improved cardiovascular health: NMN may improve blood vessel function and reduce inflammation, potentially reducing the risk of cardiovascular disease.
How can I maximise the benefits of NMN supplements?
Taking NMN supplements is only one way to support healthy ageing. It is even more important to address several lifestyle factors:
Reducing stress levels is a challenge in today’s world, but chronic stress is known to accelerate ageing. Mindfulness and meditation are excellent ways to manage stress levels. In addition, seeing a therapist can be transformative for individuals seeking to develop resilience in managing stress.
In summary, to maximise the benefits of NMN supplements, it is important to address the lifestyle factors mentioned above.
The importance of sleep to overall health is becoming increasingly recognised. Poor sleep can increase stress and inflammation levels, and lower metabolism and immune system function.
Chronic sleep deprivation has been shown to increase the risk of several health conditions, including cancer, autoimmune diseases and mental health problems. In other words, poor sleep is directly linked to shorter life expectancy.
If you are planning to invest in NMN supplements, consider investing in methods to improve sleep quality. Upgrading your bedding, using blue light blocking glasses and limiting screen time before bed are some ways to improve sleep health.
Although it is well known that diet is crucial to our health, determining the optimal diet for longevity is more difficult. Research suggests that a plant-based diet, with occasional meat and fish, may be ideal. Red meat and processed meat have been shown to accelerate ageing. In addition, a varied diet that includes at least five portions of fruit and vegetables a day is essential for boosting antioxidant levels.
What criteria should I consider when buying NMN supplements?
In your quest to find the optimal NMN supplement, it is important to understand the key factors, as marketing terminology can contribute to confusion. The most important aspects are:
It is advisable to choose a brand whose supplements are manufactured in a GMP-certified facility. GMP stands for Good Manufacturing Practice and its meaning is self-explanatory. Manufacturers in the United States and Europe typically adhere to these standards as a minimum requirement. Some manufacturers also subject their products to third-party testing. This extra layer of scrutiny ensures the absence of undesirable ingredients, heavy metals or bacteria, while also confirming the purity and accuracy of ingredient dosages.
Purity and dosage
Maximum purity is essential for NMN supplements. The best NMN brands maintain a purity of 98% or higher. The next consideration is dosage. Although there is no official recommended dosage, it is ultimately up to you to determine what works best for you. Most NMN supplements contain between 200mg and 1000mg of NMN. A higher dosage does not necessarily equate to better results. Therefore, if you are new to NMN supplements, a lower dosage may be more appropriate to start with.
While NMN is currently considered the most sought-after anti-aging ingredient, many other ingredients have been studied and show significant potential in the anti-aging field. These include quercetin, fisetin, resveratrol and spermidine, with new discoveries being made all the time.
Although NMN is at the forefront, these alternative ingredients work in different ways and retain their importance. As a result, the most effective NMN supplements incorporate a selection of these components to formulate a potent overall anti-aging blend.
During the manufacturing process of supplements, large machinery is used to combine the pills with various ingredients. Inactive ingredients known as ‘flow agents’ are added to prevent clogging. For decades, silicon dioxide and magnesium stearate have been the dominant bulking agents. However, high quality supplements use vegan alternatives such as rice flour.
Which form of NMN supplement is most beneficial?
There are several forms of NMN supplements available, including capsules, powders and sublingual tablets. However, there is no single ‘best’ form of NMN as the ideal choice depends on individual preferences and factors such as convenience, absorption and dosage.
Capsules offer a convenient and easy way to take NMN, but absorption rates may vary depending on the individual’s digestive system. Powders offer greater dosing flexibility and can be mixed with drinks or food, although they may have a slightly bitter taste.
Sublingual tablets are designed to dissolve under the tongue and may offer higher absorption rates than other forms of NMN because they bypass the digestive system. However, they may be less convenient to use and some people may find their taste or texture unpleasant.
How NMN supplements work
Some NMN studies have shown that NAD+ levels begin to rise relatively soon after starting NMN supplementation.
Some studies suggest that blood levels of NAD+ rise within about 2-3 weeks. However, the relationship between this increase and observed health benefits remains unknown.
In other words, it may take several months of consistent NMN supplementation before any noticeable benefits become apparent.
If NMN supplements are ultimately shown to improve health, it is likely that the results will be manifested at a cellular level, with tests showing improvement in blood biomarkers that determine biological age. These tests look at chronic inflammation levels as well as glycated blood levels.
Anecdotally, people report increased energy or improved skin. However, most people may not notice a significant difference in the short term.
Is it better to take NMN with food or on an empty stomach?
Recent studies have shown that NMN is easily absorbed into the bloodstream through the intestines, even on an empty stomach.
This is reassuring for those who fast and are concerned about taking NMN on an empty stomach. It is perfectly acceptable to take your NMN supplement without food in the morning.
Why are NMN supplements expensive?
NMN supplements can be expensive for a number of reasons:
Production costs: As a relatively new molecule, the production process of NMN can be complex and time-consuming, resulting in higher prices.
Limited supply: NMN is not found in large quantities in natural food sources, and the growing demand for NMN supplements has resulted in limited supply and higher prices.
Quality control: High quality NMN supplements should undergo rigorous testing and quality control measures to ensure purity and potency, which can also contribute to higher costs.
NMN and vitamin B
Although NMN is a derivative of vitamin B3, also known as niacin or nicotinamide, it is not identical to vitamin B3. NMN is a molecule that is synthesised from vitamin B3 in the body and serves as a precursor to the coenzyme nicotinamide adenine dinucleotide (NAD+), which is essential for many cellular processes such as energy production, DNA repair and gene expression.
Although both vitamin B3 and NMN contribute to NAD+ production, NMN is more readily absorbed by the body and is considered a more effective method of increasing NAD+ levels than vitamin B3. NMN is also more stable than vitamin B3 and less likely to cause flushing, a side effect often associated with high doses of vitamin B3.
When is the best time to take NMN supplements?
To improve absorption and minimise the possibility of gastrointestinal complications, it is advisable to take NMN supplements with a meal. Some researchers suggest that taking these supplements in the morning may give better results, as NAD+ concentrations tend to decrease throughout the day. Thus, synchronising NAD+ supplementation with the body’s natural circadian rhythm may be beneficial.
The right age to start taking NMN supplements
The ideal age to start NMN supplementation is currently uncertain and remains an active area of research. The decision ultimately depends on personal preference.
There is currently no consensus on the age at which people should start taking NMN supplements. Some researchers suggest that NAD+ levels may begin to decline as early as the 20s, while others believe that this decline may not become significant until later in life.
Some scientists suggest that if NAD+ levels begin to decline significantly in adulthood, it may be beneficial to start supplementation sooner rather than later.
Is it safe to take NMN supplements with resveratrol?
It is generally considered safe to take NMN supplements in conjunction with resveratrol. In fact, many people take both supplements simultaneously as they are believed to work synergistically to promote overall health and longevity.
As mentioned above, NMN is a precursor to NAD+, while resveratrol is a natural compound found in red wine, grapes and certain berries. Resveratrol has been shown to activate sirtuins, a class of proteins that help regulate cellular processes associated with ageing and stress resistance.
Essentially, resveratrol also increases NAD+ levels, albeit through different pathways.
What are the potential risks associated with taking NMN supplements?
In general, NMN supplements are considered safe and no serious adverse effects have been reported in humans at the time of writing. However, research into the long-term safety of NMN supplementation in humans remains sparse, and potential risks and side effects may include
Unforeseen long-term risks: Due to the novelty of NMN supplements, there is limited information available on their long-term safety for human consumption, and unidentified risks may be associated with prolonged use.
Gastrointestinal complications: A small number of people may experience digestive problems such as nausea, diarrhoea or bloating when taking NMN supplements.
Drug interactions: NMN may interfere with certain medications, including anticoagulants, diabetes medications, or immunosuppressants. Consultation with a healthcare professional before starting NMN supplementation is essential for those taking any medication.
Because our bodies naturally synthesise NMN from vitamin B3, it is generally well tolerated. Any adverse reactions are usually due to added ingredients such as magnesium stearate or silicon dioxide used in the manufacturing process. The main concern is the potential consequences of long-term administration of high doses of NMN. The definitive answer to this question will not be known for several years.
What NMN supplement does David Sinclair use?
David Sinclair, a renowned gerontology researcher and professor at Harvard Medical School, has confirmed in interviews and social media communications that he takes NMN supplements. However, he has refrained from revealing the specific brand or product he uses.
Sinclair has revealed that his daily regimen includes 1000mg of NMN and resveratrol. He has also added fisetin and quercetin to his routine, both of which have anti-aging properties.
Why is NMN so expensive?
A distinguishing feature of NMN is its price. High quality NMN supplements often command premium prices due to the higher cost of the raw material compared to other micronutrients.
NMN production is a complex process requiring sophisticated technology and expertise. The synthesis of NMN is a multi-step process involving several chemical reactions that require a high degree of purity to ensure safety and efficacy. The significant cost of producing high quality NMN is reflected in the price of NMN supplements.
Will NMN make me look younger?
Despite its classification as an anti-aging supplement, there is no evidence to suggest that NMN directly results in a younger appearance. Some people report smoother skin after taking NMN, but this could be due to a placebo effect.
In addition, the main factor contributing to skin ageing is exposure to the sun. Ultraviolet radiation is the most potent skin ageing agent, so using high factor sunscreens and avoiding sunbeds are the most effective means of maintaining a youthful appearance.
Is it advisable to take NMN supplements daily?
Daily use of NMN supplements is generally considered safe. However, the optimal dosage and frequency of NMN supplementation may vary depending on factors such as age, health status and individual needs.
It is worth noting that the long-term effects of daily NMN supplementation are not yet fully understood, as research in this area is ongoing.
At the time of writing, a few human studies have administered NMN supplements at doses as high as 900mg per day for 60-90 days without reporting any problems.
Can I take NMN with coffee?
There are no known interactions between NMN supplements and coffee, and it is generally considered safe to take NMN with your morning coffee.
Is it possible to get NMN naturally?
NMN is also found in certain foods, although in minute amounts compared to supplements. Some natural sources of NMN include Tomato, broccoli, Raw beef, cucumber, Edamame, Avocado.
However, it is important to recognise that the NMN content of these foods is relatively low and may not significantly increase NAD levels in the body. In addition, cooking and processing of these foods may reduce their NMN content.
Does NMN affect sleep patterns?
There is limited research on the effects of NMN supplementation on sleep. However, some studies suggest that NMN may have a positive effect on sleep quality.
One study in mice found that NMN supplementation increased brain NAD+ levels, resulting in improved sleep quality and reduced sleep fragmentation. Another human study found that NMN supplementation improved circadian rhythm function, which may have a positive effect on sleep quality.
What happens if I stop taking NMN supplements?
If you stop taking NMN supplements, your body’s NMN levels will eventually return to baseline. However, the speed at which this happens depends on several factors, including age, general health and individual metabolic rate.
There are no withdrawal symptoms associated with stopping NMN supplementation, and you can stop whenever you wish.
Best NMN supplements – conclusion
This concludes our review of the best NMN supplements currently available. Once you get past the packaging and branding, the quality of the NMN becomes the most important consideration. Look for high purity NMN produced in regions with strict standards. The most reputable NMN brands will also submit their products to third party testing, providing an additional layer of reassurance.
NMN supplements are currently attracting significant interest, but it is important to recognise that most NMN studies have been conducted on animals or small human cohorts, and more research is needed to determine the long-term safety and efficacy of NMN supplementation in humans. For those looking to start taking NMN, the top NMN brands reviewed in this article are all excellent choices.
Ben Lesser is one of the most sought-after experts in health, fitness and medicine. His articles impress with unique research work as well as field-tested skills. He is a freelance medical writer specializing in creating content to improve public awareness of health topics. We are honored to have Ben writing exclusively for Dualdiagnosis.org.